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The exact way that sulfasalazine works is unknown, but it is believed to reduce the actions of substances in the body that cause inflammation, tissue damage, and diarrhea. There is little evidence of fetal risk with sulfasalazine, as long as the expectant mother is also taking a … Sulfasalazine (SSZ), sold under the trade name Azulfidine among others, is a medication used to treat rheumatoid arthritis, ulcerative colitis, and Crohn's disease. A common dosage for adults suffering from Rheumatoid Arthritis is about 2000mg to 3000mg per day. The drug is split by the action of bacterial azoreductases in the large intestine into sulfapyridine and mesalazine (mesala … It is considered by some to be a first line treatment in rheumatoid arthritis. Sulfasalazine dose adjustment may be needed with coadministration. After an attack is treated, sulfasalazine is also used to increase the amount of time between attacks. Sulfasalazine was first used for rheumatic polyarthritis in the 1940s and in the past 2 decades has become firmly established as a disease-modifying antirheumatic drug (DMARD). Sulfasalazine is considered to be generally safer than other DMARDS such as MTX and Leflunomide. There are, however, no adequate and well-controlled studies in pregnant women. It is taken by mouth. Sulfasalazine is used to treat a certain type of bowel disease called ulcerative colitis.This medication does not cure this condition, but it helps decrease symptoms such as fever, stomach pain, diarrhea, and rectal bleeding. Sulfasalazine is taken orally as a 500mg tablet. Thus, sulfasalazine may be used during pregnancy if the physician feels the benefit outweighs the possible risk. GI side-effects are most common: Nausea (RA 19%), dyspepsia (RA 13%), anorexia, gastric distress, vomiting ... sulfasalazine should be used during pregnancy only if clearly needed. It should also be noted, however, that sulfasalazine may reduce sperm count and … Significant side effects occur in about 25% of people. Commonly these include loss of appetite, nausea, headache, and rash. Sulfasalazine is considered a pregnancy category B drug. Sulfasalazine is used to treat ulcerative colitis and to maintain remission. It is one of the “go to” DMARDs when a patient is considering pregnancy. Sulfasalazine is a substrate of breast cancer resistance protein (BCRP) and tafamidis is a BCRP inhibitor. Sulfasalazine is also compatible with breast-feeding in a healthy, full-term infant. The dosage of sulfasalazine should be individually adjusted according to the patient’s tolerance and response to the treatment. Additionally, there have not been ill effects on pregnant animals given high doses of sulfasalazine. Dosage usually begins with one 500mg tablet per day and dosage is eventually increased by 500mg to see how your body reacts to the drug. The delayed-release tablets, Azulfidine® (EN-tabs), are also used to treat rheumatoid arthritis and juvenile rheumatoid arthritis. Sulfasalazine: Sulfasalazine (at doses up to 2g/day) with folate supplementation is safe to continue whilst trying to conceive and throughout pregnancy. Talazoparib: (Major) Avoid coadministration of sulfasalazine with talazoparib due to increased talazoparib exposure. Pregnancy: Teratogenic Effects : Pregnancy Category B. Reproduction studies have been performed in rats and rabbits at doses up to 6 times the human dose and have revealed no evidence of impaired female fertility or harm to the fetus due to sulfasalazine. Breast-feeding : The amount of sulfasalazine that passes into the maternal milk is … Dose . Disease-modifying anti-rheumatic drugs (DMARDs) vary widely according to their safety in pregnancy. Of breast cancer resistance protein ( BCRP ) and tafamidis is a BCRP inhibitor and... 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